Top 10 Supplements for Anxiety in 2025
Modern life can feel overwhelming — from endless notifications to tight deadlines and constant pressure to perform, anxiety has become a common companion for many. But you’re not powerless. Alongside habits like mindfulness, exercise, and good sleep, the right supplements can help calm your nervous system and support emotional balance.
Here are the top 10 supplements for anxiety in 2025, trusted by wellness experts and backed by science.
1. Magnesium Glycinate
Magnesium is one of the most studied minerals for reducing anxiety. Magnesium Glycinate, in particular, is highly bioavailable and gentle on the stomach. It helps regulate neurotransmitters, promoting relaxation and better sleep.
Best taken at night to unwind and support a deeper, more restorative sleep.
2. L-Theanine
Naturally found in green tea, L-Theanine promotes alpha brain waves — the ones associated with calm focus. It helps reduce stress without causing drowsiness, making it perfect for daytime use.
Pairs well with caffeine to ease jitters while improving attention.
3. Ashwagandha
This ancient adaptogen has surged in popularity for good reason. Ashwagandha helps your body adapt to stress, reduces cortisol levels, and improves resilience over time. Multiple studies have shown its ability to lower anxiety and improve mood.
Consistency is key — take daily for a few weeks to feel the full effects.
4. Rhodiola Rosea
Another powerful adaptogen, Rhodiola helps balance the stress response and prevent burnout. It’s especially helpful when you’re mentally exhausted or emotionally drained.
Best taken in the morning to support stamina and mental clarity throughout the day.
5. GABA (Gamma-Aminobutyric Acid)
GABA is a naturally occurring neurotransmitter that slows down brain activity and induces a sense of calm. Supplementing with GABA can help relax a racing mind and improve sleep quality.
Use in the evening or before high-stress situations like presentations or flights.
6. CBD (Cannabidiol)
CBD has become one of the most talked-about supplements for anxiety. It interacts with the endocannabinoid system to promote calm, reduce stress, and even help with sleep. Make sure to use a high-quality, third-party tested product.
Start with a low dose and adjust based on how your body responds.
7. Vitamin B Complex
B vitamins (especially B6, B9, and B12) are critical for neurotransmitter function. Deficiencies can lead to mood imbalances and increased anxiety. A quality B-complex can support brain health and help regulate mood.
Opt for methylated forms for better absorption and effectiveness.
8. Omega-3 Fatty Acids (EPA & DHA)
Found in fish oil or algae-based supplements, Omega-3s help reduce inflammation and improve communication between brain cells. Studies show they may significantly reduce anxiety, particularly EPA-rich formulas.
Take daily with meals for best results.
9. Passionflower
This calming herb is often used in teas and tinctures for its sedative effects. Passionflower increases GABA levels in the brain, which can help quiet anxious thoughts and support better sleep.
Great in the evening or when you need to unwind after a long day.
10. Valerian Root
Known as a natural sedative, Valerian Root has been used for centuries to calm the nervous system. It’s especially helpful for anxiety that interferes with sleep.
Use sparingly — best for short-term or situational anxiety and insomnia.
Final Thoughts
There’s no one-size-fits-all solution for anxiety. What works best often depends on your body, your lifestyle, and your stress levels. Supplements can be a powerful ally — but they work best when paired with daily habits that support your mental and emotional health.
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