NAD+ Levels and Alzheimer’s: What a New Study Found and What It Really Means

There’s a new Alzheimer’s paper doing the rounds because it connects NAD+ with disease severity and shows something dramatic in mouse models.

If you have been searching “NAD boosters”, “how to increase NAD+”, or “NAD and Alzheimer’s”, this is the study people are referencing.

Quick summary

• Researchers link worse Alzheimer’s pathology with more disrupted NAD+ homeostasis in brain tissue
• NAD+ related signals differ between Alzheimer’s brains and healthy controls
• In multiple Alzheimer’s mouse models, a compound improved disease markers and cognition, even in advanced stages
• This is not proof that boosting NAD+ reverses Alzheimer’s in humans

Source paper: Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain, Cell Reports Medicine (2025)

What is NAD+ and why is everyone talking about it?

NAD+ (nicotinamide adenine dinucleotide) is a molecule found in every cell. It plays a key role in turning food into usable energy and supporting cellular repair processes.

NAD+ levels tend to decline with age, which is why it comes up so often in conversations around energy, ageing, and brain health.

This study puts NAD+ in the spotlight because it links disrupted NAD+ balance with mechanisms involved in Alzheimer’s disease.

What the study actually looked at

The researchers approached Alzheimer’s through a “brain energy balance” lens.

They analysed human brain tissue data and found that Alzheimer’s severity tracked with disruption of NAD+ homeostasis. They also identified molecular pathways that appeared more preserved in people who had Alzheimer’s pathology but did not develop dementia.

Alongside the human data, they tested a pharmacologic approach in several Alzheimer’s mouse models.

What happened in the mouse models

In the animal studies, the compound used by the researchers improved several key outcomes:

• Reduced markers of Alzheimer’s pathology
• Improved cognitive performance
• Benefits were seen even in advanced stages of disease

This is the part that grabbed attention. Reversal of advanced disease features in mice is rare and always sparks interest.

What this does and does not mean

This study is important, but it is easy to misinterpret.

• It does not prove Alzheimer’s can be reversed in humans
• It does not prove that NMN, NR, niacin, or NAD IVs treat dementia
• Mouse model success does not guarantee human success

What it does show is that NAD+ balance appears closely tied to brain health and disease mechanisms, making it a promising area for future research.

Why NAD+ is trending right now

NAD+ sits at the intersection of energy, focus, ageing, and brain health.

Outside of Alzheimer’s, people search NAD+ in relation to:

• Low energy and fatigue
• Brain fog and focus
• Healthy ageing and longevity
• Staying sharp under stress

This study adds weight because it connects NAD+ balance directly to brain disease biology, not just general wellbeing.

How people support NAD+ in daily life

Supporting NAD+ starts with basics, not supplements.

• Consistent sleep and wake times
• Regular movement and exercise
• Enough protein and micronutrients
• Managing stress and recovery

Some people also choose NAD+ precursors like NMN or NR as part of a routine, especially during busy or demanding periods.

As always, supplements are there to support habits, not replace them.

Where My Dailys fits

Our approach is simple. Build the routine first, then support it with clean, consistent supplementation.

The My Dailys Stack is designed around the daily pillars most people struggle with:

• Vitamin D3 + K2 for daily resilience and immunity
• NMN to support cellular energy routines
• Lion’s Mane for focus and mental clarity
• Magnesium Glycinate for sleep and recovery

Shop the full stack here: My Dailys Stack

Read the original research

PubMed: https://pubmed.ncbi.nlm.nih.gov/41435831/

Full journal article: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1

Final thought

This study reinforces something simple. Brain health is deeply tied to energy and consistency.

You do not need extreme protocols. You need a solid foundation, small daily habits, and enough support to keep showing up.

Small habits. Better energy. Real momentum.

Medical note: This article is for educational purposes only and is not medical advice.