The First Human NMN Study That Changed Everything (Irie et al., 2020)
For years, NMN (nicotinamide mononucleotide) had been studied in animals with incredible results — better energy, improved metabolism, and slower signs of aging. But until 2020, one big question remained: does NMN actually work in humans?
That question was answered by Irie et al., 2020 — the first human clinical trial to show that oral NMN safely increases NAD⁺ levels in healthy adults. It’s one of the most important studies in the world of longevity research and a huge reason NMN is now being talked about everywhere.
What the Study Looked At
The research, conducted in Japan, involved a randomized, double-blind, placebo-controlled human trial — the gold standard in science. Healthy men were given a single oral dose of NMN to test whether it could raise NAD⁺ metabolites in the blood.
After taking NMN, researchers measured significant increases in NAD⁺ metabolites — proving that NMN was absorbed and active in the human body. Just one dose made a measurable difference, and most importantly, it was completely safe and well tolerated.
Read the full study on PubMed.
Why This Study Was a Turning Point
Before 2020, NMN’s potential was based mostly on mouse and cell studies. The Irie et al. trial gave scientists — and the rest of us — clear human evidence that NMN could do what researchers had hoped: raise NAD⁺ levels safely in real people.
This opened the door for more human trials exploring NMN’s effects on energy, metabolism, endurance, and even cognitive health. Since then, several studies have built on this foundation, showing that consistent NMN use may help improve insulin sensitivity, aerobic performance, and age-related fatigue.
What This Means for You
In simple terms: NMN really works at a cellular level. By helping your body restore NAD⁺ — the molecule that powers energy production and DNA repair — you’re supporting the systems that keep you feeling young, focused, and resilient.
Think of NAD⁺ as your body’s battery charge. When it’s full, your cells can do their jobs efficiently. When it’s low, you feel tired, sluggish, and foggy. NMN helps top up that cellular battery.
Our Take at My Dailys
When we started My Dailys, we wanted supplements that actually backed up their claims with real science — not hype. That’s why we chose NMN as part of our My Dailys Stack. It’s one of the most researched longevity ingredients out there, and the Irie et al. study is proof of how powerful it can be when used consistently.
We also made sure our NMN was third-party tested for purity and made without fillers or binders — just clean, effective ingredients that your body can actually use.
Try My Dailys NMN
If you’re ready to experience what science has been proving since 2020, it’s time to see what NMN can do for your focus, energy, and long-term wellness. Discover a clean, proven supplement that fits into your daily routine.
Shop My Dailys NMN here: https://www.mydailys.health/products/nmn-capsules
Disclaimer: This article is for informational purposes only and is not medical advice. Always consult a qualified healthcare professional before starting any supplement routine.
